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Target intelligence / Profile preview
Thymosin beta 15A (TMSB15A)
- Target
- TMSB15A
- Molecular classification
- Actin-binding protein, Cytoskeletal protein regulator, Other (protein coding gene; member of the beta thymosin family)
01
Overview
Thymosin beta 15A is a member of the beta-thymosin family of small regulatory proteins, primarily expressed in the cytosol, where it binds and sequesters actin monomers, inhibiting actin polymerization and thereby influencing cell shape, migration, and motility[1][4]. The protein is upregulated in multiple malignancies and contributes to tumor cell migration, invasiveness, and metastasis through interaction with oncogenic and inflammatory signaling pathways such as IL-6/JAK/STAT3 and TGF-β[4]. TMSB15A serves as a promising biomarker for diagnosis, prognosis, and response prediction in cancers like gastric and triple-negative breast cancer[2][4].
- Other names
- TB15Athymosin β15thymosin beta-15ATMSL8 (previous symbol)
02
Mechanism of action
No approved drugs or experimental compounds with defined mechanism targeting Thymosin beta 15A; preclinical studies suggest possible inhibition could interfere with cell proliferation and migration[4]
03
Biological functions
Actin monomer bindingPositive regulation of cell migrationInhibition of actin polymerizationRegulation of cytoskeletonCell motilityCell proliferation
04
Disease associations
Cancer (Gastric cancer, neuroblastoma, breast cancer, prostate cancer, glioma, hepatocellular carcinoma, head and neck cancer)Inflammation (implicated by pathway enrichment in IL-6/JAK/STAT3 and other inflammatory signaling)Other (Focal segmental glomerulosclerosis 1)
05
Biomarkers
Diagnostic biomarker in gastric cancer (high specificity and accuracy for GC vs normal tissue)Predictive biomarker for chemotherapy response in triple-negative breast cancerPrognostic marker for poor overall survival in gastric cancer
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