Thymosin beta-15C (TMSB15C)

Thymosin beta-15C is a peptide hormone and actin-binding protein encoded by the TMSB15C gene. It is secreted by thymic epithelial cells (TECs) and plays a key role in regulating the actin cytoskeleton by sequestering G-actin monomers, thus modulating actin polymerization and cell motility[1][2]. TMSB15C is specifically involved in maintaining the spatial organization of TECs within the thymus, influencing thymic architecture, epithelial cell differentiation, and the development and selection of thymocytes (T cell precursors)[1]. It is the highest-affinity actin-binding member of the beta-thymosin family, which includes related proteins like thymosin beta-4 and beta-10[1]. Although its biological functions are fundamental to immune system and thymus development, it is not currently recognized as a direct therapeutic target or clinical biomarker. There are no known drugs or therapies targeting this molecule. Additional distinction: Thymosin beta-15C is structurally and functionally related to other beta-thymosins, such as thymosin beta-4, which share actin-sequestering properties and cell motility regulation, but TMSB15C's functions are primarily linked to the immune microenvironment of the thymus, rather than broad systemic effects or direct therapeutic applications[2][1].

Other names

Thymosin beta-15CTMSB15Cthymosin beta-15B-likeTMSB15Bthymosin beta-15B

Not applicable; no known pharmacological modulators or approved drugs target Thymosin beta-15C