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Target intelligence / Profile preview
Thyroid Gland
- Molecular classification
- Endocrine gland
01
Overview
The thyroid gland is a butterfly-shaped endocrine gland located in the neck that produces thyroid hormones (T3 and T4), which regulate metabolism, and calcitonin, which regulates blood calcium levels. Disorders of the thyroid gland include hyperthyroidism, hypothyroidism, goitre, nodules, and cancer.
02
Mechanism of action
Drugs either replace deficient thyroid hormones (levothyroxine), inhibit thyroid hormone synthesis (methimazole, propylthiouracil), or destroy thyroid tissue (radioactive iodine).
03
Biological functions
Hormone productionRegulation of metabolismCalcium homeostasisGrowth and development
04
Disease associations
HyperthyroidismHypothyroidismGoitreThyroid nodulesThyroid cancer
05
Safety considerations
Hyperthyroidism (over-replacement of thyroid hormones)Hypothyroidism (under-replacement of thyroid hormones)Agranulocytosis (methimazole, propylthiouracil)Liver damage (propylthiouracil)Hypocalcemia (following thyroidectomy)Radiation exposure (radioactive iodine)
06
Interacting drugs
Levothyroxine
3 more in the full profile.
07
Biomarkers
TSH levelsT4 levelsT3 levelsThyroglobulin levelsCalcitonin levels
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