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Thyroid Hormone Receptor Alpha
- Molecular classification
- Nuclear hormone receptor, Transcription factor
01
Overview
Thyroid hormone receptor alpha (TRα), also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear hormone receptor that functions as a high-affinity receptor for thyroid hormones, especially triiodothyronine (T3) and thyroxine (T4). It regulates gene expression by binding to DNA and recruiting coactivators or corepressors depending on ligand binding. Key roles include regulation of metabolism, heart rate, and developmental transitions. Mutations in *THRA* can cause nongoitrous congenital hypothyroidism type 6.
- Other names
- NR1A1c-erbA-1THRA1THRA2EAR7ERBA1c-erbA-alphac-erbA-I
02
Mechanism of action
Transcription factor: repressor when unliganded; activator when liganded. Binds to DNA and regulates gene expression in response to thyroid hormones.
03
Biological functions
Regulation of transcriptionRegulation of metabolismRegulation of heart rateRegulation of developmentLigand-dependent transcriptional regulation
04
Disease associations
Nongoitrous congenital hypothyroidism type 6Resistance to thyroid hormone
05
Safety considerations
Potential for off-target effects due to interaction with other nuclear receptorsThyroid hormone imbalances can lead to cardiovascular and neurological complications
06
Interacting drugs
Triiodothyronine (T3)
1 more in the full profile.
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