Thyroid hormone receptor-associated protein 3 (THRAP3)

Thyroid hormone receptor-associated protein 3 (THRAP3) is a nuclear protein that functions in pre-mRNA splicing and remains associated with spliced mRNA, likely interacting with the exon junction complex[1][3][4]. It acts as a transcription coactivator, notably enhancing the activity of the CLOCK-BMAL1 heterodimer on circadian gene targets, and participates in the positive regulation of the circadian clock[1][6]. THRAP3 is implicated in the stability of specific mRNAs, regulation of gene expression, alternative splicing, response to DNA damage, and mRNA decay[1][3][4]. It is not considered a classical drug target such as a receptor or an enzyme, but alterations in its function have been associated with certain cancers, including soft tissue sarcoma and telangiectatic osteogenic sarcoma[1]. Common alternative names and aliases include TRAP150 and BCLAF2[1][2].

Other names

TRAP150BCLAF2BCLAF1 and THRAP3 family member 2Thyroid hormone receptor-associated protein complex 150 kDa componentTR-associated protein, 150-kDaSNARP complex component