Thyroid hormone receptor-interacting protein 13 (TRIP13)

Thyroid hormone receptor-interacting protein 13 (TRIP13) is a member of the AAA+ ATPase family that functions as a critical regulator of chromosome segregation during cell division. TRIP13 localizes to kinetochores, where it interacts with spindle assembly checkpoint components (notably, Mad2 and p31comet), ensuring accurate chromosome separation and appropriate cell cycle progression. In meiosis, TRIP13 is essential for meiotic checkpoint control and homologous recombination. In cancer, TRIP13 is frequently overexpressed, driving tumor cell proliferation, migration, invasion, resistance to apoptosis, and is linked to chemoresistance through disruption of the mitotic checkpoint complex and activation of pathways such as PI3K/Akt. Its strong association with poor clinical prognosis makes it an appealing, though challenging, therapeutic target and cancer biomarker.

Other names

Pachytene checkpoint protein 2 homologPCH216E1-BPHPV16 E1 protein-binding proteinTR-interacting protein 13TRIP-1316E1BPHuman papillomavirus type 16 E1 protein-binding proteinThyroid hormone receptor interactor 13Thyroid receptor-interacting protein 13MVA3OOMD9OZEMA9SH3TC1/TRIP13 fusion

Drugs or inhibitors targeting TRIP13 aim to restore mitotic checkpoint function and re-sensitize cancer cells to chemotherapies (e.g., taxanes, bortezomib), often by restoring Mad2 or mitotic checkpoint complex activity.