Thyroid hormone receptor interactor 11 (TRIP11)

Thyroid hormone receptor interactor 11 (TRIP11) is a protein predominantly associated with the Golgi apparatus, where it functions as a membrane tether required for vesicle tethering and maintains the structure and function of the Golgi complex[1][2][5][6][7]. It is crucial for intracellular protein transport—particularly in the trafficking between the endoplasmic reticulum (ER) and the Golgi—and also serves as a coactivator for thyroid hormone receptors, enhancing thyroid hormone receptor-mediated transcription in the presence of ligands like triiodothyronine[2][7]. Mutations in TRIP11 lead to severe skeletal disorders such as achondrogenesis type 1A and odontochondrodysplasia, reflecting its especially important function in chondrocytes during cartilage and bone development[1][2][4][5]. TRIP11 is not a druggable receptor, enzyme, transporter, or typical therapeutic target, and no interacting drugs or clinical biomarkers are currently known[7][8].

Other names

GMAP-210GMAP210Thyroid receptor-interacting protein 11Trip230CEV14ACG1AODCDODCD1