Thyroid hormone receptor interactor 13 pseudogene

This entry refers to a pseudogene annotated as related to "Thyroid hormone receptor interactor 13" (TRIP13) but does not encode a functional protein and is not considered a drug target. Pseudogenes are relic DNA sequences that often do not produce functional products. The validated therapeutic target and protein-coding gene is TRIP13 (Thyroid hormone receptor interactor 13), which participates in chromosome recombination, meiosis, and the spindle assembly checkpoint, and interacts with thyroid hormone receptors[1][2]. However, ENSG00000261056 refers to a *non-functional pseudogene*, and not to the TRIP13 protein. Essential context: - If you are seeking information about a therapeutic target with a role in meiotic recombination, spindle checkpoint, or thyroid hormone receptor interaction, you should query the *TRIP13 protein-coding gene* (e.g., ENSG00000071539, not ENSG00000261056)[1]. - Pseudogenes are typically not drug targets, do not produce active proteins, and do not have standard biological or disease roles attributed in therapeutic contexts. Summary of what is incorrect: - *Thyroid hormone receptor interactor 13 pseudogene* is not a valid therapeutic target. - Information relevant for protein or drug targets should be referenced to the *protein-coding gene TRIP13* rather than this pseudogene[1].