Target intelligence / Profile preview

Thyroid Peroxidase (TPO)

Target: TPO
Molecular classification: Enzyme, Peroxidase

Overview

Thyroid peroxidase (TPO) is a membrane-bound enzyme essential for the synthesis of thyroid hormones. It catalyzes the oxidation of iodide and the iodination of thyroglobulin, forming T3 and T4. TPO is a major autoantigen in autoimmune thyroid diseases, and its activity is inhibited by thionamide drugs used to treat hyperthyroidism. Genetic mutations in TPO can lead to congenital hypothyroidism.

Other names: ThyroperoxidaseIodide Peroxidase

Mechanism of action

Thionamide drugs inhibit TPO activity, blocking the synthesis of new thyroid hormones.

Biological functions

Oxidation of iodideIodination of tyrosine residuesThyroid hormone synthesis

Disease associations

Hashimoto's ThyroiditisGraves' DiseaseCongenital HypothyroidismThyroid dyshormonogenesis

Safety considerations

Drug-induced hypothyroidism (due to excessive TPO inhibition)

Interacting drugs

Methimazole

2 more in the full profile.

Biomarkers

Anti-TPO antibodies (diagnosis of autoimmune thyroid diseases)

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