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Target intelligence / Profile preview
Ticagrelor Active Metabolite (AR-C124910XX)
- Target
- AR-C124910XX
- Molecular classification
- Small molecule, Drug metabolite
01
Overview
The major active metabolite of ticagrelor, AR-C124910XX, is formed primarily by CYP3A4 and CYP3A5 in the liver. It is an equipotent reversible antagonist of the platelet P2Y12 receptor, contributing significantly to the antiplatelet effects of ticagrelor. Its formation and elimination can be influenced by other drugs and patient-specific factors, affecting overall therapeutic efficacy and safety.
- Other names
- AR-C124910XXTicagrelor metabolite
02
Mechanism of action
Reversible antagonist of the platelet P2Y12 receptor
03
Biological functions
Platelet aggregation inhibitionP2Y12 receptor antagonism
04
Disease associations
Cardiovascular diseaseThrombotic disorders
05
Safety considerations
Bleeding riskDrug interactions affecting CYP3A activity
06
Interacting drugs
Ticagrelor
3 more in the full profile.
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