Target intelligence / Profile preview

Tick-borne encephalitis virus non-structural protein 1 (None)

Target
None
Molecular classification
Glycoprotein, Non-structural protein, Flavivirus protein
01

Overview

Tick-borne encephalitis virus (TBEV) non-structural protein 1 (NS1) is a highly conserved glycoprotein encoded by the TBEV genome. NS1 plays critical roles in immune evasion, pathogenesis, and viral replication. Secreted NS1 modulates host immune responses and its immunogenicity is exploited for diagnostic purposes to differentiate between natural infection and vaccine-induced immunity.

Other names
TBEV NS1NS1
02

Mechanism of action

N/A

03

Biological functions

Immune evasionViral replicationModulation of host immune responsesActivation of Toll-like receptors (TLRs)Inhibition of complement system
04

Disease associations

Tick-borne encephalitisNeuroinvasive disease
05

Biomarkers

Anti-TBEV NS1 IgG antibodies (diagnostic marker for recent/ongoing natural infection)

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