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Tick-borne encephalitis virus (TBEV) non-structural protein 1 (NS1) is a highly conserved glycoprotein encoded by the TBEV genome. NS1 plays critical roles in immune evasion, pathogenesis, and viral replication. Secreted NS1 modulates host immune responses and its immunogenicity is exploited for diagnostic purposes to differentiate between natural infection and vaccine-induced immunity.
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