TIE-2 receptor (Tie2)

TIE-2 (also known as TEK or Angiopoietin-1 receptor) is a receptor tyrosine kinase primarily expressed in endothelial cells. It plays a crucial role in blood vessel formation, remodeling, and maintenance of vascular integrity. TIE-2 is activated by angiopoietins, particularly Angiopoietin-1, which promotes vessel stability and quiescence. Angiopoietin-2 can act as either an agonist or antagonist depending on the context. Dysregulation of TIE-2 is implicated in various diseases, including vascular malformations and tumor angiogenesis, making it a potential therapeutic target.

Other names

Angiopoietin-1 receptorTyrosine-protein kinase receptor TEKTEK

Agonist or antagonist of TIE-2 signaling, depending on the specific agent and context. Agonists promote receptor oligomerization and autophosphorylation, while antagonists block ligand binding or downstream signaling.