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Target intelligence / Profile preview
TIE2 Receptor (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
The TIE2 receptor, also known as Angiopoietin-1 receptor or TEK tyrosine kinase, is a receptor tyrosine kinase primarily expressed in endothelial cells. It is essential for blood vessel maturation, remodeling, and stability during embryonic development and postnatal angiogenesis. Aberrant TIE2 signaling is implicated in various vascular diseases including venous malformations and cancer-related angiogenesis. It interacts with Angiopoietin-1 (agonist) and Angiopoietin-2 (context-dependent agonist/antagonist).
- Other names
- Angiopoietin-1 ReceptorTEK tyrosine kinaseCD202BTEK
02
Mechanism of action
Agonist-mediated receptor activation; Antagonist-mediated receptor inhibition; Inhibition of receptor tyrosine kinase activity
03
Biological functions
AngiogenesisBlood vessel maturationBlood vessel remodelingBlood vessel stabilizationCommunication between endothelial cells and stromal cells
04
Disease associations
Venous malformationsCancerTumor angiogenesisVascular diseasesNonfunctioning pituitary neuroendocrine tumors
05
Safety considerations
Potential for off-target effects due to broad expression in vascular endothelial cells.Disruption of normal angiogenesis processes.
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