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Target intelligence / Profile preview
TIE2 Tyrosine Kinase (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
TIE2, also known as TEK tyrosine kinase, is a receptor tyrosine kinase predominantly expressed in endothelial cells. It plays a critical role in the regulation of angiogenesis—the formation and maintenance of blood vessels—as well as lymphatic vessel development. TIE2 is essential for vascular remodeling, maturation, and integrity during both physiological and pathological processes. Dysregulation of TIE2 signaling is implicated in several diseases, including cancer, inflammatory diseases, and congenital disorders. Pharmacological inhibition/blockade of TIE2 activity is being explored as an antiangiogenic strategy for cancer therapy.
- Other names
- TEK tyrosine kinaseAngiopoietin-1 receptorCD202b antigenEndothelial tyrosine kinase 2 (Tek)Tunica interna endothelial cell kinaseTyrosine-protein kinase receptor TEK/TIE-2/hTIE 2/p140 TEK
02
Mechanism of action
Inhibition/blockade of TIE2 activity (antiangiogenic)
03
Biological functions
Blood vessel sprouting and branchingVascular integrity/maturationEndothelial cell survival/proliferation/migrationAngiogenesis regulation
04
Disease associations
CancerTumor angiogenesisRheumatoid arthritisCongenital glaucomaVenous malformationsInflammatory diseases
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