Tigger transposable element-derived protein 1 (TIGD1)

Tigger transposable element-derived protein 1 (TIGD1) is a human protein encoded by the TIGD1 gene, part of the tigger subfamily of the pogo superfamily of DNA-mediated transposons. TIGD1 contains a DNA-binding helix-turn-helix (HTH) motif and a DDE endonuclease domain, sharing structural similarity with mammalian centromere protein B (CENP-B). Although its precise physiological roles are not fully defined, TIGD1 is implicated in regulating cell proliferation, migration, and gene expression, mainly due to its upregulation in many cancers. High TIGD1 expression is correlated with poor prognosis and increased tumor aggressiveness, making it of interest both as a biomarker and a possible therapeutic target. Pathways associated with TIGD1 include PI3K/AKT, FOXO, and p53—key regulators of cancer cell survival, cell cycle, and apoptosis. TIGD1 may influence tumor immune response and chemotherapy sensitivity, but further research is needed to clarify its mechanisms and therapeutic potential.

Other names

EEYOREtigger transposable element derived 1Tigger transposable element-derived protein 1

Not established due to lack of TIGD1-specific inhibitors. In experimental models, siRNA/shRNA-mediated TIGD1 knockdown decreases cancer cell proliferation and migration, suggesting putative inhibition would suppress tumor progression