Tigger transposable element-derived protein 6 (TIGD6)

Tigger transposable element-derived protein 6 (TIGD6) is a human protein encoded by the TIGD6 gene, a member of the tigger subfamily of the pogo superfamily of DNA-mediated transposons[1][3]. These proteins are evolutionarily related to DNA transposases found in lower organisms, such as fungi and nematodes, and are distantly related to the Tc1/mariner family of transposases[1][3]. TIGD6 is structurally similar to mammalian centromere protein B and likely retains nucleic acid binding capacity but is not known to possess transposase enzymatic activity[3]. Its precise biological function in humans is not well defined; the primary annotation is based on sequence homology and structural domains, such as the helix-turn-helix CENPB-type domain[1]. Published associations link TIGD6 with rare neurodevelopmental disorders, but there is no evidence for a direct role in common human diseases or its utility as a therapeutic target[3]. TIGD6 encodes a domesticated transposon-derived protein of unknown physiological function in humans[1][3]. It is not currently recognized as a therapeutic, diagnostic, or pharmacological target. Most information on TIGD6 focuses on its evolutionary origin, molecular structure, and rare disease associations. No drugs or biomarker applications are described.

Other names

TIGD6Tigger transposable element-derived protein 6DKFZp761E2110TIGD6_HUMANPrevious GeneCards identifiers (e.g., GC05M149442)