Tight junction protein 1 pseudogene

This entry refers to a pseudogene related to the TJP1 gene, which encodes the tight junction protein 1 (also known as Zonula occludens-1 or ZO-1) in humans. The pseudogene does not encode a functional protein and is not itself involved in tight junction structure or function. Pseudogenes typically arise from duplication or retrotransposition events and, unlike their parental protein-coding genes, do not produce functional protein products; their biological roles, if any, are generally limited or non-protein-coding and poorly characterized[4]. Context: - The functional TJP1 gene is involved in cell-cell adhesion and barrier functions in epithelial and endothelial tissues and can be relevant in disease and as a biomarker[1][3][5], but the pseudogene is none of these. - The Ensembl ID ENSG00000229389 aligns with a pseudogene, not with the functional protein coding gene, and should not be considered a true protein, receptor, or therapeutic target. Summary: This is not a valid therapeutic target, and the entry is marked as incorrect for use in a molecular target list. If you intended to refer to the actual tight junction protein 1 (TJP1), you should use the protein-coding gene (Ensembl: ENSG00000104067), not the pseudogene.

Other names

tight junction protein 1 (zona occludens 1) pseudogenetight junction protein 1 (zonula occludens 1) pseudogene