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Tight Junctions (N/A)

Target: N/A
Molecular classification: Multiprotein complex, Cell adhesion complex

Overview

Tight junctions are multiprotein complexes forming selectively permeable seals between adjacent epithelial/endothelial cells. Their core structure consists mainly of claudins and occludin linked via scaffolding proteins like ZOs to the cytoskeleton. They play critical roles in tissue compartmentalization by regulating paracellular permeability and maintaining cell polarity; their dysfunction is implicated in various diseases.

Other names: Zonula occludensOccluding Junction

Biological functions

Barrier functionSelective permeabilityCell polarityTissue compartmentalization

Disease associations

Inflammatory bowel disease (IBD)Celiac diseaseCancerNeurological disorders involving blood-brain barrier breakdown

Safety considerations

Disruption or dysfunction can lead to loss of barrier integrity

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