Target intelligence / Profile preview

Grass Pollen Allergens

Molecular classification
Protein, β-expansins, Profilins
01

Overview

Grass pollen allergens are a diverse group of proteins found in grass pollen that trigger allergic reactions. Major allergen groups include Group 1 (β-expansins) and Group 5. These allergens induce IgE-mediated immune responses, leading to hay fever, asthma, and other allergic symptoms. Cross-reactivity with certain fruits and vegetables can cause oral allergy syndrome. Diagnosis involves skin prick testing or specific IgE blood tests. Management includes avoidance, pharmacotherapy, and immunotherapy.

Other names
Timothy grass pollen allergensPhleum pratense allergensPooideae pollen allergensGroup 1 allergens (grass pollen)Group 5 allergens (grass pollen)
02

Mechanism of action

Antihistamines block histamine receptors; corticosteroids reduce inflammation; immunotherapy aims to desensitize individuals to specific allergens.

03

Biological functions

AllergenIgE bindingImmune response activationPollen-food cross-reactivity
04

Disease associations

Allergic rhinitis (hay fever)AsthmaConjunctivitisOral Allergy Syndrome (OAS)
05

Safety considerations

Anaphylaxis (severe allergic reaction)Side effects of antihistamines (e.g., drowsiness)Side effects of corticosteroids (e.g., immunosuppression)Local reactions to skin prick testsRisk of asthma exacerbation
06

Interacting drugs

Antihistamines

4 more in the full profile.

07

Biomarkers

Specific IgE levels to grass pollen allergensSkin prick test reactivity

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