Target intelligence / Profile preview

Timothy Grass Pollen Antigen

Molecular classification
Protein, Allergen, Beta-expansin (Phl p 1), Glycoprotein
01

Overview

Timothy grass pollen antigen refers to a group of allergenic proteins found in the pollen of Timothy grass (Phleum pratense), a major cause of seasonal allergic rhinitis (hay fever) and conjunctivitis. Key allergens include Phl p 1 (a beta-expansin), Phl p 2, Phl p 3, Phl p 4, and Phl p 6. These antigens trigger IgE-mediated and T-cell mediated immune responses in allergic individuals, leading to inflammation and allergic symptoms. Extracts containing these antigens are used for diagnosis (skin prick tests) and treatment (sublingual immunotherapy).

Other names
Phleum pratense pollen antigenPhl p 1Phl p 2Phl p 3Phl p 4Phl p 6Timothy grass allergen
02

Mechanism of action

Allergen immunotherapy aims to desensitize the patient by repeated exposure to the allergen, modifying the immune response. Antihistamines block histamine receptors, and corticosteroids reduce inflammation.

03

Biological functions

Immune responsePollen tube growth (Phl p 1)Allergenicity
04

Disease associations

Allergic rhinitisHay feverAllergic conjunctivitis
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Safety considerations

Risk of anaphylaxis during allergen immunotherapyLocal allergic reactions (e.g., itching, swelling) to allergen immunotherapyCross-reactivity with other grass pollens and some foods
06

Interacting drugs

Allergen immunotherapy (e.g., GRASTEK®)

2 more in the full profile.

07

Biomarkers

IgE levels specific to Timothy grass pollen antigensSkin prick test reactivity

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