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Tissue Factor (TF)
- Target
- TF
- Molecular classification
- Integral membrane glycoprotein, Receptor
01
Overview
Tissue factor (TF), also known as coagulation factor III, is an integral membrane glycoprotein that initiates blood coagulation. It acts as the high-affinity receptor and essential cofactor for plasma factor VII/VIIa, triggering the extrinsic pathway of blood coagulation following vascular injury. Aberrant expression or exposure of TF contributes significantly to disease states such as atherosclerosis, sepsis, and cancer.
- Other names
- Coagulation Factor IIIPlatelet Tissue FactorThromboplastinCD142
02
Mechanism of action
TF binds with high affinity to factor VII/VIIa, leading to the activation of factors IX and X, ultimately resulting in thrombin generation and fibrin clot formation.
03
Biological functions
Initiation of blood coagulationHemostasisActivation of protease activated receptors (PARs)Cell signaling
04
Disease associations
AtherosclerosisSepsisCancerThrombosisDisseminated Intravascular Coagulation (DIC)
05
Safety considerations
Risk of thrombosis with excessive TF activationPotential for disseminated intravascular coagulation (DIC) in sepsis
06
Interacting drugs
Recombinant Factor VIIa
3 more in the full profile.
07
Biomarkers
Elevated TF levels in plasma/microvesicles (e.g., in cancer patients)TF expression in atherosclerotic plaques
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