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Target intelligence / Profile preview
Tissue Factor Pathway Inhibitor (TFPI)
- Target
- TFPI
- Molecular classification
- Protease Inhibitor, Kunitz-type protease inhibitor
01
Overview
Tissue factor pathway inhibitor (TFPI) is a key endogenous anticoagulant protein that regulates the initiation of blood coagulation. It acts as the primary inhibitor of the tissue factor (TF)-induced coagulation pathway, thereby modulating both bleeding and clotting disorders. TFPI contains three Kunitz-type protease inhibitor domains. It inhibits early steps in blood coagulation by blocking two key procoagulant complexes, directly inhibiting FXa and inhibiting the FVIIa–tissue factor complex.
02
Mechanism of action
Direct inhibition of FXa via Kunitz domain 2; inhibition of FVIIa-tissue factor complex via Kunitz domain 1 upon binding to FXa.
03
Biological functions
Regulation of blood coagulationInhibition of Factor XaInhibition of FVIIa-Tissue Factor complex
04
Disease associations
Bleeding disordersThrombosis
05
Safety considerations
Potential for bleeding complications with increased inhibitionPotential for thrombotic complications with decreased inhibition
06
Interacting drugs
Heparin
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