Tissue healing pathway

The "tissue healing pathway" collectively refers to the orchestrated processes required to repair and regenerate tissue after injury or damage. This involves phases such as hemostasis (cessation of bleeding), inflammation (immune cell infiltration and pathogen clearance), proliferation (cellular migration, proliferation, and extracellular matrix deposition), and remodeling (restoration of tissue architecture and function). Multiple cell types, including macrophages, fibroblasts, keratinocytes, and endothelial cells, as well as cytokines, growth factors, and signaling cascades such as the hedgehog, calcium, and reactive oxygen species pathways, drive these processes. Imbalances in these pathways can result in delayed healing, chronic wounds, or pathological scarring[1][2][3][4][5][6][7][8]. The phrase “tissue healing pathway” is too broad and nonspecific to serve as a molecular therapeutic target; instead, it encompasses numerous individual molecular targets (such as growth factor receptors, matrix metalloproteinases, and inflammatory cytokines), each of which may be a subject of drug development. Therefore, further specification is required to map this functional concept to a distinct and actionable molecular entity.

Other names

Wound healing pathwaytissue repair pathwaywound repair

Promote cell migration and proliferation, modulate immune response, enhance angiogenesis, regulate extracellular matrix synthesis and remodeling, reduce inflammation