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Target intelligence / Profile preview
Tissue Kallikrein 2 (KLK2)
- Target
- KLK2
- Molecular classification
- Serine protease, Enzyme
01
Overview
Tissue kallikrein 2 (KLK2), also known as kallikrein-related peptidase 2, is a trypsin-like serine protease predominantly expressed in prostatic tissue. It plays a crucial role in seminal clot liquefaction and sperm motility. KLK2 is implicated in prostate cancer progression, promoting tumor proliferation, invasion, angiogenesis, and metastasis. It is regulated by androgens and interacts with AR coregulators. Targeting KLK2 holds promise as a therapeutic strategy for prostate cancer.
- Other names
- Kallikrein-related peptidase 2
02
Mechanism of action
KLK2 inhibitors suppress the growth of castration-resistant prostate cancer cells and increase apoptosis rates while arresting cell cycle progression at G1 phase.
03
Biological functions
Semen liquefactionSperm motilityProteolysisActivation of TGFβ signaling pathwaysPAR activationAngiogenesis
04
Disease associations
Prostate cancerAcute myeloid leukemia
05
Safety considerations
Potential for off-target effects due to serine protease activityInhibition may disrupt normal semen function
06
Biomarkers
Elevated KLK2 levels in prostate cancerKLK2 SNPs (e.g., rs198977) for prostate cancer risk/prognosis
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