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Target intelligence / Profile preview
Kallikrein (KLK)
- Target
- KLK
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Kallikreins are a subgroup of serine proteases involved in various physiological processes including blood pressure regulation, inflammation, and semen liquefaction. They are synthesized as inactive pro-proteins and activated by proteolytic cleavage. Dysregulation of kallikreins has been implicated in cancer, cardiovascular disorders, and inflammatory conditions, making them potential therapeutic targets and biomarkers.
- Other names
- Plasma KallikreinTissue KallikreinsKLKB1KLK1KLK2KLK3KLK4KLK5KLK6KLK7KLK8KLK9KLK10KLK11KLK12KLK13KLK14KLK15
02
Mechanism of action
Kallikreins are serine proteases that cleave peptide bonds in proteins, particularly kininogens, to release kinins like bradykinin, which mediates vasodilation and inflammation. They also play roles in semen liquefaction and extracellular matrix remodeling.
03
Biological functions
Blood pressure regulationInflammation controlSemen liquefactionExtracellular matrix remodelingSkin desquamationAngiogenesis
04
Disease associations
CancerCardiovascular disordersInflammatory conditions
05
Safety considerations
Off-target effects due to broad substrate specificityPotential for hypotensive effectsUnintended activation of inflammatory pathways
06
Biomarkers
KLK3 (Prostate-Specific Antigen - PSA) for prostate cancerKLKs as potential biomarkers in various cancers
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