Target intelligence / Profile preview

Tissue Plasminogen Activator (tPA)

Target: tPA
Molecular classification: Serine protease, Enzyme

Overview

Tissue plasminogen activator (tPA) is a serine protease enzyme that catalyzes the conversion of plasminogen to plasmin, the primary enzyme responsible for dissolving blood clots. It plays a crucial role in fibrinolysis and is used therapeutically to treat acute ischemic events like stroke, myocardial infarction, and pulmonary embolism. tPA's activity is tightly regulated by inhibitors like PAI-1, and its therapeutic use carries risks of bleeding.

Mechanism of action

Converts plasminogen to plasmin, leading to fibrin clot dissolution.

Biological functions

FibrinolysisExtracellular matrix remodelingCell migration

Disease associations

ThrombosisEmbolismStrokeMyocardial InfarctionPulmonary EmbolismDeep Vein Thrombosis

Safety considerations

Hemorrhage (especially intracranial hemorrhage)AngioedemaReperfusion injury

Interacting drugs

Recombinant human tPA (e.g., Alteplase, Reteplase, Tenecteplase)

1 more in the full profile.

Biomarkers

tPA levels (in plasma)PAI-1 levels (in plasma)Fibrin degradation products (e.g., D-dimer)

Beyond the preview

Go deeper on Tissue Plasminogen Activator (tPA).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Tissue Plasminogen Activator (tPA).

Explore the full profile