Tissue repair/regeneration pathways

"Tissue repair and regeneration pathways" refer to a collection of interrelated signaling and cellular events that restore structural and functional integrity following tissue injury. Key molecules include growth factors (FGF, EGF, HGF), cytokines (IL-1α, IL-6, IL-8), caspases (traditionally linked to apoptosis but also implicated in regeneration), reactive oxygen species (which modulate signaling), and components of the extracellular matrix. Major pathways implicated are Wnt, Hippo, Notch, BMP, FGF, TGF-β, Shh, and planar cell polarity pathways[2][3]. These pathways orchestrate inflammation, cell proliferation, migration, differentiation, and remodeling, with crosstalk ensuring appropriate repair. Dysregulation can result in pathological conditions such as fibrosis, cancer, or chronic non-healing wounds. The term does not correspond to a single therapeutic target, but understanding these pathways is essential for the development of regenerative therapies and intervention strategies[1][2][3][4]. Caveat: This entry does not fit the standard requirements for a molecular target. It is a high-level, descriptive term encompassing many molecular entities and processes. For structured drug discovery or target profiling, it should be replaced by specific pathway members (e.g., "Fibroblast growth factor receptor 1", "Transforming growth factor beta receptor", etc.)[2][3][4].

Other names

Tissue repair pathwaysTissue regeneration pathwaysTissue healing mechanismsRegenerative pathways

Not applicable for a single molecule; various drugs modulate elements of these pathways (e.g., growth factor agonists/antagonists, anti-inflammatory agents, pro-angiogenic compounds)[2][4]