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Tissue Regeneration via Paracrine Effect
- Molecular classification
- Cytokine, Growth factor, Chemokine, MicroRNA, Extracellular vesicle
01
Overview
Tissue regeneration via the paracrine effect describes a mechanism involving multiple soluble mediators released from therapeutic donor/stem/progenitor cells that orchestrate endogenous repair processes across diverse tissues. These secreted molecules influence neighboring cells to stimulate proliferation/migration, promote angiogenesis, modulate immunity, inhibit apoptosis, and limit fibrosis. This paradigm shift has significant implications for regenerative medicine strategies moving forward.
- Other names
- Paracrine signaling in tissue regenerationStem cell paracrine effectMesenchymal stem cell paracrine effectRegenerative paracrine effect
02
Mechanism of action
Secretion of bioactive molecules from therapeutic donor/stem/progenitor cells acts locally on resident/damaged tissue, influencing cellular processes such as proliferation, migration, angiogenesis, immunity, apoptosis, and fibrosis.
03
Biological functions
Cell proliferationCell migrationAngiogenesisImmune modulationAnti-apoptosisAnti-fibrosisTissue repair
04
Disease associations
Myocardial infarctionWound healingBone regenerationSpinal cord injuryIschemic heart diseaseChronic wounds/burnsMusculoskeletal injuriesNeurodegenerative diseases
05
Safety considerations
Potential for unwanted angiogenesisOff-target effects of paracrine factorsImmunogenicity of donor cells or secreted factorsDifficulty in controlling the local concentration of paracrine factorsTumorigenesis
06
Interacting drugs
VEGF agonists/antagonists
3 more in the full profile.
07
Biomarkers
Levels of VEGFLevels of TGF-βLevels of FGF2Levels of Angiopoietin-2Levels of IL-6Specific microRNA expression profilesMarkers of angiogenesisMarkers of inflammationMarkers of fibrosis
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