Tissue repair and wound healing pathways

Tissue repair and wound healing pathways encompass a coordinated sequence of cellular and molecular events designed to restore tissue integrity following injury [1]. This process is categorized into four distinct yet overlapping phases: hemostasis, inflammation, proliferation, and remodeling [2]. It involves a diverse array of cell types, including platelets, neutrophils, macrophages, fibroblasts, and endothelial cells, which communicate via complex signaling networks involving growth factors like PDGF and TGF-beta [3]. Dysregulation of these pathways is a hallmark of various pathologies, ranging from chronic non-healing ulcers in diabetic patients to excessive scarring and systemic fibrosis [1, 2]. Pharmacological intervention typically targets specific components of these pathways, such as growth factor receptors or inflammatory mediators, to promote efficient repair and minimize adverse outcomes [3].

Other names

Wound healing cascadeTissue regeneration pathwaysCutaneous wound healing process

Modulation of growth factor signaling (e.g., PDGF receptor activation), regulation of inflammatory cytokine release, enzymatic debridement of necrotic tissue, and stimulation of extracellular matrix deposition [1, 3].