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Tissue surface proteins" is not a specific molecule or receptor but rather a broad and non-standard term referring to the diverse set of proteins located on the exterior (surface) of cells within tissues. These include many different molecular classes such as receptors (e.g., G protein-coupled receptors, receptor tyrosine kinases), transporters, enzymes, cell adhesion molecules, and others[4]. The collective set of these is sometimes called the "surfaceome"[4]. Because this term does not refer to a single defined target but instead encompasses hundreds to thousands of distinct entities with varied structure and function[4], it cannot be considered a canonical therapeutic target. Instead, individual members within this group—such as CD antigens or specific membrane-bound receptors—may serve as drug targets in cancer immunotherapy and other fields[1][4]. The lack of specificity makes "Tissue surface proteins" an incorrect or overly broad entry for structured drug target information.
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