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Target intelligence / Profile preview
Tissue Transglutaminase 2 (TG2)
- Target
- TG2
- Molecular classification
- Enzyme, Transglutaminase, GTPase, ATPase, Protein Disulfide Isomerase, Kinase
01
Overview
Tissue Transglutaminase 2 (TG2) is a multifunctional enzyme involved in various cellular and extracellular processes. It catalyzes protein crosslinking, deamidation, GTP/ATP hydrolysis, protein disulfide isomerization, and protein phosphorylation. TG2 plays key roles in cell adhesion, migration, growth, survival, apoptosis, differentiation, and ECM organization. Its involvement in various diseases, including wound healing, inflammation, autoimmunity (notably celiac disease), neurodegeneration, vascular remodeling, tumor growth/metastasis, and tissue fibrosis, makes it a potential therapeutic target.
- Other names
- Tissue transglutaminasetTGTGase2
02
Mechanism of action
Inhibition of transamidation/crosslinking activity, inhibition of deamidation activity, modulation of GTPase/ATPase activity.
03
Biological functions
Cell adhesionCell migrationCell growthCell survivalApoptosis regulationCell differentiationExtracellular matrix organizationTransamidation/crosslinkingDeamidationGTP/ATP hydrolysisProtein disulfide isomerizationProtein phosphorylation
04
Disease associations
Wound healingInflammationAutoimmunityCeliac diseaseNeurodegenerationVascular remodelingTumor growthMetastasisCancer stemness regulationTissue fibrosis
05
Safety considerations
Modulation of TG2 activity may have pleiotropic effects due to its diverse functions.Inhibition of TG2 could impair wound healing and ECM stability.
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