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Target intelligence / Profile preview
Tissue-type Plasminogen Activator (tPA)
- Target
- tPA
- Molecular classification
- Serine Protease, Enzyme
01
Overview
Tissue-type plasminogen activator (tPA) is a serine protease enzyme primarily responsible for catalyzing the conversion of plasminogen to plasmin, the major enzyme involved in breaking down blood clots (fibrinolysis). It is found on endothelial cells lining blood vessels and plays a central role in maintaining vascular patency by dissolving fibrin clots. Recombinant forms are used as thrombolytic agents for acute ischemic stroke, myocardial infarction, and pulmonary embolism.
- Other names
- T-PATPAPLATVascular ActivatorExtrinsic Plasminogen Activator
02
Mechanism of action
Catalyzes the conversion of plasminogen to plasmin, leading to fibrin clot breakdown.
03
Biological functions
FibrinolysisPlasminogen ActivationClot DissolutionHemostasisInflammation ModulationImmune Response ModulationNeuronal Signaling (indirectly)
04
Disease associations
Ischemic StrokeMyocardial InfarctionPulmonary EmbolismDeep Vein ThrombosisThrombotic Events
05
Safety considerations
Hemorrhagic StrokeHead TraumaBleeding RiskExcessive/Fatal Bleeding
06
Interacting drugs
Alteplase
3 more in the full profile.
07
Biomarkers
tPA antigen leveltPA activity
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