Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
TLC domain containing 3B (TLCD3B)
- Target
- TLCD3B
- Molecular classification
- Transmembrane protein, Enzyme (ceramide synthase), TLC (Tram-Lag-CLN8) domain-containing protein
01
Overview
TLC domain containing 3B (TLCD3B) is a protein-coding gene that encodes a transmembrane protein containing a conserved TLC domain. This protein functions as a ceramide synthase, contributing to cellular lipid composition, particularly ceramides, which are essential structural components of cellular membranes. TLCD3B is expressed in multiple tissues and is associated with inherited retinal dystrophies, such as cone-rod dystrophy. It has potential regulatory connections to PPAR-gamma signaling and metabolic disease, as suggested by studies in mice. The gene has several aliases, most commonly FAM57B and TLC3B. Key molecular features include its enzymatic activity and its membership in the TLC domain family, which also includes ceramide synthases and proteins involved in membrane lipid regulation[2][7][1].
- Other names
- FAM57BTLC3BFamily with sequence similarity 57 member BFP1188
02
Mechanism of action
No direct mechanism of action for drugs targeting TLCD3B is reported; possible indirect modulation via PPAR-gamma pathway[3][5].
03
Biological functions
Ceramide synthesisRegulation of lipid compositionPotential involvement in peroxisome proliferator-activated receptor gamma (PPAR-gamma) signaling[2][3][5]
04
Disease associations
Cone-rod dystrophy 22 (and 2) (genetic retinal disorder)[2][7]16p11.2 proximal deletion syndrome (genetic association)[2]Potential relevance to obesity (mouse ortholog)[2]
Beyond the preview
Go deeper on TLC domain containing 3B (TLCD3B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on TLC domain containing 3B (TLCD3B).