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TLC domain-containing protein 1 (TLCD1)
- Target
- TLCD1
- Molecular classification
- Enzyme (acyltransferase; specifically lysophosphatidylethanolamine acyltransferase), Transmembrane protein, Other (TLC domain-containing protein)
01
Overview
TLC domain-containing protein 1 (TLCD1) is a conserved multi-pass transmembrane acyltransferase enzyme, specifically a lysophosphatidylethanolamine acyltransferase[1]. It regulates cellular phospholipid composition by modulating the acyl chain of phosphatidylethanolamine, a key mitochondrial and plasma membrane lipid[1][2][6][7]. TLCD1 inhibits the incorporation of fluidizing phospholipids with omega-3 long-chain polyunsaturated fatty acids, thereby increasing membrane rigidity[6][7]. It is implicated in processes such as membrane assembly, phospholipid homeostasis, and membrane lipid distribution[1][2][3][5]. Disruption of TLCD1 is associated with metabolic diseases such as non-alcoholic steatohepatitis and rare genetic disorders including spastic paraplegia[1][2]. Its exact physiological and pathological roles are still being defined, but it is recognized as a molecular target in membrane biology and lipid-associated diseases[1][2][6].
- Other names
- TLCD1TLC domain containing 1CalfacilitinTLC domain-containing protein 1
02
Biological functions
Regulation of cellular phospholipid compositionMembrane assemblyPhospholipid homeostasisRegulation of membrane lipid distributionPromotes membrane rigidity by inhibiting incorporation of omega-3 LCPUFA phospholipids
03
Disease associations
Non-alcoholic steatohepatitis (NASH), promoting disease progressionSpastic paraplegia 81, autosomal recessiveCarnitine palmitoyltransferase I deficiencyOther (potential roles in lipid-associated disease and mitochondrial dysfunction inferred from function)
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