TLR adaptor interacting with SLC15A4 on the lysosome (TASL)

TLR adaptor interacting with SLC15A4 on the lysosome (TASL) is an innate immune adaptor protein encoded by the CXorf21 gene, identified as a partner of the endolysosomal transporter SLC15A4[1][3][5]. TASL is specifically required for signaling by endolysosomal Toll-like receptors (TLR7, TLR8, TLR9), where it forms a complex with SLC15A4. This complex recruits and activates the transcription factor IRF5—a pivotal event for the production of type I interferon and pro-inflammatory cytokines in response to pathogenic nucleic acids. TASL contains a conserved pLxIS motif that mediates IRF5 recruitment, and its localization and function are strictly dependent on SLC15A4 binding. Loss of TASL disrupts IRF5 activation without affecting NF-κB or MAPK pathways, indicating a unique, non-redundant role in TLR-driven type I interferon responses. The TASL-SLC15A4 module is genetically and functionally implicated in autoimmune disorders, including systemic lupus erythematosus, making TASL a promising new target for therapeutic strategies aiming to modulate pathogenic type I interferon signaling[1][3][4][5].

Other names

CXorf21FLJ115775430427O19Rikprotein CXorf21uncharacterized protein CXorf21TLR adapter interacting with SLC15A4 on the lysosome