TM2 domain containing 1 pseudogene

TM2 domain containing 1 pseudogene is a human genomic sequence closely related to the TM2 domain containing 1 (TM2D1) gene, which encodes a beta-amyloid peptide-binding protein structurally related to the G protein-coupled receptor superfamily[1][7]. However, as a **pseudogene**, ENSG00000244652 does not encode a functional protein product and is generally considered non-functional by standard definitions[2][5][8][11]. Pseudogenes like this can arise from gene duplication or retrotransposition events and typically do not produce protein, nor do they have direct therapeutic or biomarker relevance under current knowledge[2][5][8]. **Key context:** - The functional TM2D1 gene encodes a protein involved in beta-amyloid peptide binding and G protein signaling and has been studied in the context of Alzheimer’s disease[1][7]. - The **pseudogene** variant, such as ENSG00000244652, lacks evidence of protein-coding potential and direct functional or disease relevance[2][5][8][11]. If a functional target or therapeutic relevance is sought, use "TM2 domain containing 1" (TM2D1, ENSG00000162604), **not the pseudogene**.

Other names

TM2D1PTM2D1 pseudogeneTM2 domain containing 1 pseudogene