TM2 domain-containing protein 2 (TM2D2)

TM2 domain-containing protein 2 (TM2D2) is a membrane protein containing a module structurally related to the seven transmembrane domain G protein-coupled receptor superfamily, though it is not itself a canonical GPCR[2][3]. It is homologous to beta-amyloid binding protein (BBP), but, unlike BBP, does not regulate responses to beta-amyloid peptide. TM2D2 may be involved in regulatory processes affecting cell death or proliferation, as suggested by its sequence features and some experimental parallels to TM2D family members implicated in Notch signaling regulation and neurodevelopment in model organisms[1][2][3]. Mutations in related TM2D genes (e.g., TM2D3) are associated with neurological deficits and neurodegenerative phenotypes in animal models, but there is limited direct evidence for TM2D2’s role in human disease outside of its association with a congenital myopathy[1][3]. It is not currently an established therapeutic target and no drugs or biomarkers are known for this protein.

Other names

BLP1BBP-like protein 1beta-amyloid-binding protein-like protein 1TM2D2TM2 domain-containing protein 2

Not established; no drugs currently target this protein specifically