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Target intelligence / Profile preview
TM4SF1 antisense RNA 1 (TM4SF1-AS1)
- Target
- TM4SF1-AS1
- Molecular classification
- Long non-coding RNA, Non-coding RNA
01
Overview
TM4SF1 antisense RNA 1 (TM4SF1-AS1) is a long non-coding RNA transcribed from the TM4SF1 locus on chromosome 3. It does not encode protein but interacts with multiple cellular proteins, including Pur-α and YB-1. TM4SF1-AS1 is found predominantly in the cytoplasm, where it can inhibit apoptosis by promoting stress granule formation in cancer cells and activating interferon-related signaling. Its expression is upregulated in several cancers, suggesting oncogenic functions and a role in tumorigenesis. Upregulation of TM4SF1-AS1 may serve as a diagnostic or prognostic biomarker for certain cancers, and the molecule is being explored as a potential novel therapeutic target in oncology.
- Other names
- TM4SF1-AS1TM4SF1 antisense RNA 1 (non-protein coding)TM4SF1 antisense RNA 1
02
Biological functions
Inhibits apoptosis in cancer cellsPromotes stress granule formation under cellular stressActivates interferon signalingInteracts with RNA-binding proteins (Pur-α, YB-1)
03
Disease associations
Cancer (oncogenic roles in gastric cancer, hepatocellular carcinoma, lung cancer)Possibly regulates early tumorigenesis
04
Biomarkers
TM4SF1-AS1 expression is a candidate biomarker for cancer progression or prognosis
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