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Target intelligence / Profile preview
TM4SF19 antisense RNA 1 (TM4SF19-AS1)
- Target
- TM4SF19-AS1
- Molecular classification
- Long non-coding RNA
01
Overview
TM4SF19 antisense RNA 1 (TM4SF19-AS1) is a long non-coding RNA that does not encode a protein. It is highly expressed in head and neck squamous cell carcinoma (HNSCC) cells and tissues. Functional studies show that its knockdown impairs cell proliferation, migration, invasion, and epithelial-mesenchymal transition in HNSCC cell lines, as well as tumor growth in vivo. Mechanistically, TM4SF19-AS1 acts in the cytoplasm as a competing endogenous RNA (ceRNA), sponging microRNA-153-3p to upregulate its target LAMC1, and also interacts with the RNA-binding protein HNRNPC to stabilize LAMC1 mRNA. These results suggest TM4SF19-AS1 plays an oncogenic role in HNSCC and may be of clinical value as a novel biomarker, but it is not considered a classical therapeutic target like a receptor, enzyme, or transporter[1][3].
- Other names
- TM4SF19-AS1TM4SF19 antisense RNA 1 (non-protein coding)
02
Biological functions
Regulation of cell proliferationRegulation of cell migrationRegulation of cell invasionEpithelial-mesenchymal transition (EMT) regulationCompeting endogenous RNA (ceRNA) activity (miRNA sponge)
03
Disease associations
Cancer (specifically head and neck squamous cell carcinoma)
04
Biomarkers
Potential biomarker for diagnosis or prognosis in head and neck squamous cell carcinoma
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