Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
TMEM105 long non-coding RNA (TMEM105)
- Target
- TMEM105
- Molecular classification
- Long non-coding RNA, Regulatory RNA
01
Overview
TMEM105 long non-coding RNA (TMEM105) is a non-protein-coding transcript that plays a crucial role in aerobic glycolysis and cancer development. It is highly upregulated in breast cancer and pancreatic cancer cells, where it promotes tumor cell proliferation and migration. TMEM105 functions by increasing the expression of LDHA, a key enzyme in glycolysis, and stabilizing the oncogenic β-catenin protein through proteasome inhibition. These activities make it a potential therapeutic target and biomarker for cancer diagnosis and prognosis[4][6]. As a member of the long non-coding RNA family, TMEM105 adds an additional layer of regulatory control over gene expression in the cancer microenvironment, and its structural characteristics confer functional plasticity and disease relevance[1][3].
- Other names
- TMEM105FLJ38792transmembrane protein 105
02
Mechanism of action
Not applicable for drugs; TMEM105 acts by modulating gene expression and protein stability: Upregulation of glycolytic enzymes (especially LDHA) Enhancement of β-catenin protein stability (via proteasome pathway)
03
Biological functions
Regulation of gene expression, particularly aerobic glycolysisPromotion of cancer cell proliferation and migrationUpregulation of lactate dehydrogenase A (LDHA) expression, influencing glycolytic enzyme activityEnhancement of β-catenin protein stability through the proteasome pathway
04
Disease associations
Cancer (notably breast cancer and pancreatic cancer)Tumor growth and progressionPossible role in metabolic reprogramming during glucose deficiency
05
Safety considerations
Not reported; therapeutic targeting of lncRNAs can carry risks of off-target effects and challenges in RNA delivery.
06
Biomarkers
TMEM105 expression level in breast cancer and pancreatic cancer cells
Beyond the preview
Go deeper on TMEM105 long non-coding RNA (TMEM105).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on TMEM105 long non-coding RNA (TMEM105).