TMEM123 divergent transcript (TMEM123-DT)

TMEM123 divergent transcript (TMEM123-DT) is a non-coding RNA gene annotated in genomic databases as an antisense or divergent transcript relative to the protein-coding gene TMEM123. This transcript does not encode a protein and, to date, lacks evidence as a biologically characterized or therapeutic target. All available mechanistic and disease association data pertains to the TMEM123 protein (also known as Porimin/KCT-3), a plasma membrane glycoprotein involved in immune cell migration and tumor immune surveillance, not to TMEM123-DT[1][2]. The protein-coding gene TMEM123 is sometimes confused with its divergent transcript TMEM123-DT, but all major literature and functional studies to date pertain only to TMEM123, not TMEM123-DT[1][2]. The term "TMEM123-DT" refers to a non-coding RNA, not a conventional therapeutic target (such as a receptor, enzyme, or transporter). TMEM123-DT is not a receptor, enzyme, or other conventional target and is likely included in error when searching for protein/gene therapeutic targets. All functional relevance is for TMEM123, not TMEM123-DT[1][2][3].

Other names

TMEM123-DT