TMEM167B divergent transcript (TMEM167B-DT)

TMEM167B divergent transcript (TMEM167B-DT) is a long non-coding RNA transcribed in the region of the TMEM167B gene. It is produced by divergent transcription—a phenomenon in which the promoter of a protein-coding gene also initiates transcription in the opposite direction, generating non-coding RNA. Such transcripts rarely encode proteins and are typically involved in local gene regulation, especially during development and cell differentiation[2][3]. Divergent transcripts often remain chromatin-associated and are co-expressed with their paired protein-coding gene. While some lncRNAs derived from divergent transcription have described regulatory roles (such as chromatin modification or influencing transcriptional pausing), TMEM167B-DT itself has not been directly tied to specific disease processes, protein interactions, or drug mechanisms. Overall, TMEM167B-DT reflects a growing understanding that many regions of the mammalian genome are pervasively transcribed, often without producing proteins, but may still contribute to complex regulatory networks influencing gene activity and epigenetic states[2][3]. In summary: TMEM167B-DT is a non-coding RNA, not a classical therapeutic target, and is best described as a divergent transcript with potential regulatory roles, but with no direct involvement in known drug interactions or disease pathways[1][2][3].

Other names

TMEM167B-DTTMEM167B divergent transcript