TMEM246 antisense RNA 1 (TMEM246-AS1)

TMEM246 antisense RNA 1 (TMEM246-AS1) is a long non-coding RNA (lncRNA) gene, located on chromosome 9 and classified as an antisense transcript relative to the TMEM246 gene[1][6]. As an lncRNA, TMEM246-AS1 does not encode a protein but may regulate gene expression, likely through mechanisms typical for antisense RNAs such as modulation of transcription, chromatin structure, or RNA stability[1][4]. There is currently very limited direct functional or mechanistic information specifically concerning TMEM246-AS1. Diseases reported to be associated with TMEM246-AS1 include cataract, but mechanistic links and broader biomedical relevance are not established[1]. There is no evidence that TMEM246-AS1 is a validated therapeutic target, interacts with any drugs, or is clinically actionable. For most lncRNAs—especially antisense types—functions are proposed to include cis- or trans-regulation of neighboring or overlapping protein-coding genes, but these roles for TMEM246-AS1 remain uncharacterized[4].

Other names

TMEM246-AS1