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Target intelligence / Profile preview
TMEM51 antisense RNA 1 (TMEM51-AS1)
- Target
- TMEM51-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein-coding RNA
01
Overview
TMEM51 Antisense RNA 1 (TMEM51-AS1) is a long non-coding RNA located on chromosome 1p36.21, spanning ~40,650 base pairs. It is expressed in multiple tissues, including brain, ovary, and prostate. TMEM51-AS1 regulates gene expression involved in energy metabolism, RNA methylation, and DNA repair. In cancer biology, its expression is generally downregulated in colorectal cancer and positively correlates with survival in chromophobe renal cell carcinoma and laryngeal squamous cell carcinoma. High TMEM51-AS1 expression inhibits tumor cell immune escape and chemokine-mediated malignancy, serving as a tumor suppressor in certain cancers. It is not a protein or classical therapeutic target, but is increasingly recognized for its biomarker and regulatory functions within the non-coding RNA landscape.
- Other names
- FLJ23703C1orf126TMEM51-AS1
02
Mechanism of action
Not applicable; TMEM51-AS1 is not directly targeted by pharmacological agents, but its expression level modifies cancer cell sensitivity to anticancer drugs and immunotherapies indirectly
03
Biological functions
Regulation of gene expressionModulation of DNA repair processesAssociation with RNA methylationParticipation in energy metabolism pathwaysSignal transduction modulation (via regulatory networks)Negative regulation of immune checkpoints and chemokines in cancer
04
Disease associations
Chromophobe renal cell carcinoma (biomarker/prognostic correlation)Colorectal cancer (tumor suppressor function)Laryngeal squamous cell carcinoma (potential biomarker)
05
Safety considerations
No notable safety concerns or therapeutic challenges reported relevant to therapeutic targeting, as the molecule is not itself targeted by drugs. Its role is primarily as a biomarker and regulatory RNA
06
Biomarkers
TMEM51-AS1 RNA expression level in tumors is used as a biomarker for prognosis in chromophobe renal cell carcinoma/laryngeal squamous cell carcinoma and as a candidate for efficacy selection in colorectal cancer
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