TMEM9 domain family member B (TMEM9B)

TMEM9 domain family member B (TMEM9B) is a single-span, glycosylated type I transmembrane protein primarily localized to intracellular acidic organelles such as lysosomes and endosomes. TMEM9B directly interacts with endosomal ClC-3 and ClC-4 chloride/proton transporters, inhibiting their function and modulating their activation kinetics. It is involved in the positive regulation of NF-κB and TNF-α signaling pathways, and its expression is associated with both neurodevelopmental and inflammatory conditions, including certain cancers and autoimmune diseases such as Wegener's granulomatosis. TMEM9B’s function suggests a role as a regulatory protein influencing membrane trafficking, cytokine production, and local inflammatory responses, making it a potential biomarker and therapeutic target in diseases related to membrane transporter homeostasis and immune dysregulation

Other names

C11orf152310004K06RIKD7H11orf15TMEM9 domain family, member BTMEM9BUNQ712/PRO1375ICRFP703B1614Q5.3RGD1310775

Inhibition or modulation of endosomal/lysosomal Cl─/H⁺ transporter function, regulation of NF-κB and TNF-α signaling, and transcriptional control of cytokine production