TMF1-regulated nuclear protein 1 (TRNP1)

TMF1-regulated nuclear protein 1 (TRNP1) is a short-lived, low-complexity nuclear DNA-binding protein encoded by the TRNP1 gene. It is crucial for cellular proliferation, especially in neural stem cells, and plays a major role in brain development and cortical folding, acting as a key regulator of gene expression during neurogenesis. TRNP1 interacts with and organizes several nuclear membrane-less compartments, such as nucleoli, nuclear speckles, and heterochromatin; it can self-assemble and phase separate via intrinsically disordered regions to modulate nuclear architecture and cellular functions. TRNP1 levels in the brain correlate with cortical complexity and folding. Disease associations include neurodevelopmental disorders and cancer, where its proliferative capacity may underlie oncogenic potential. No drugs directly target TRNP1 yet, but its unique mechanisms provide future opportunities for therapeutic modulation in brain development and cancer.

Other names

TMF-regulated nuclear protein 1TRNP1C1orf225TRNPTNRP

Drugs targeting such proteins would likely modulate DNA binding, phase separation, or protein-protein interaction networks relevant for cell proliferation and neural development