Target intelligence / Profile preview

TMPRSS11B N-terminal like (pseudogene) (TMPRSS11BNL)

Target
TMPRSS11BNL
Molecular classification
Other (Pseudogene)
01

Overview

TMPRSS11BNL (TMPRSS11B N-terminal like) is classified as a pseudogene in humans and does not encode a functional protein. Its sequence is homologous to the protein-coding gene TMPRSS11B but lacks a functional product. There is no evidence it functions as a receptor, enzyme, or any conventional drug target, nor does it have characterized biological activity or relevance as a drug target[3]. Key clarification: *TMPRSS11BNL* is not the same as the functional TMPRSS11B gene (Transmembrane protease, serine 11B), which is a serine protease with tumorigenic roles in lung cancer[1][2]. The pseudogene is genomically related but is not itself a receptor, enzyme, or therapeutic target, and should not be confused with TMPRSS11B. All disease, functional, and drug-targeting information refers to TMPRSS11B, not TMPRSS11BNL[1][2][3].

Other names
TMPRSS11B N-Terminal Like (Pseudogene)TMPRSS11B N Terminal-LikeFLJ41562TMPRSS11B N-Terminal Like, PseudogeneTMPRSS11B N-Terminus-Like ProteinTransmembrane Protease Serine 11B-Like ProteinTransmembrane Protease, Serine 11B Pseudogene[3]
02

Disease associations

Squamous cell carcinoma, head and neck (association as a locus, not as a functional product)[3]

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