TMPRSS6 antisense RNA 1 (TMPRSS6-AS1)

TMPRSS6 antisense RNA 1 (TMPRSS6-AS1) is a non-coding RNA gene transcribed antisense to the TMPRSS6 coding gene. While TMPRSS6 (Transmembrane serine protease 6, also known as matriptase-2) is a well-studied protein involved in regulating iron homeostasis and is a validated therapeutic target in iron-refractory iron deficiency anemia and beta-thalassemia[3][4][5][1], TMPRSS6-AS1 itself is an RNA molecule without evidence of direct protein-coding function or established biological activity. No data currently support its role as a direct therapeutic target, as a biomarker, or as having interacting drugs. Its primary significance in public databases is as an annotated non-coding RNA gene, not as a drug target[2]. Clarification: - This query appears to confuse the therapeutic significance of TMPRSS6 (a well-defined transmembrane serine protease and drug target) with TMPRSS6-AS1, which is a non-coding (antisense) RNA. Antisense oligonucleotide therapeutics target the TMPRSS6 gene transcript/output, not the TMPRSS6-AS1 RNA[1][3]. - TMPRSS6-AS1 is not an established therapeutic target; its function—if any—is not sufficiently characterized in the literature. - For therapeutic relevance in anemia and iron overload, see TMPRSS6 (Transmembrane serine protease 6, or matriptase-2)[3][5][4][1].

Other names

TMPRSS6-AS1TMPRSS6 antisense RNA 1