TMSB4X pseudogene 8 (TMSB4XP8)

**TMSB4X pseudogene 8** (TMSB4XP8) is a processed pseudogene and not a protein-coding gene. While the parent gene, TMSB4X (Thymosin beta 4, X-linked), encodes a highly conserved actin-sequestering peptide involved in cytoskeleton regulation, cell migration, and tumor progression, TMSB4XP8 itself is classified as a pseudogene and is not known to produce a functional protein or possess independent biological or therapeutic relevance[4]. Pseudogenes such as TMSB4XP8 are generally non-functional remnants of genes that have lost their protein-coding potential through evolution, though some may be expressed at the RNA level without known physiological or therapeutic implications[4][5]. **Key clarifications:** - **is_target: false** — TMSB4XP8 is a pseudogene, not a validated therapeutic target (such as a receptor, enzyme, transporter, or signaling protein)[4]. - **is_incorrect: true** — This entry is not a protein-coding therapeutic target. The parent gene, TMSB4X, is a well-characterized actin regulator and cancer-associated target, but TMSB4XP8 itself is not functionally active or used in drug targeting or biomarker strategies[4][1][2][3]. - **TMSB4XP8 versus TMSB4X:** The functional/therapeutic and biological information in the literature (cell migration, cancer, ferroptosis, etc.) refers specifically to the TMSB4X gene/protein, and not to its pseudogenes such as TMSB4XP8[1][2][3][4]. **Summary:** **TMSB4XP8 is a processed pseudogene related to Thymosin beta 4, X-linked (TMSB4X), and not a functional protein or therapeutic target. All major biological and disease associations pertain to the functional TMSB4X gene, not the pseudogene TMSB4XP8**[4][1][2][3].

Other names

Thymosin beta 4, X-linked pseudogene 8TMSB4XP8