Target intelligence / Profile preview

Tumor Necrosis Factor-Inducible Gene 6 Protein (TSG-6)

Target: TSG-6
Molecular classification: Glycoprotein, Hyaladherin, Secreted protein

Overview

Tumor necrosis factor-inducible gene 6 protein (TSG-6) is a secreted glycoprotein known for its anti-inflammatory and tissue-protective functions. It plays a significant role in extracellular matrix organization during tissue remodeling. TSG-6 modulates inflammatory responses, interacts with matrix molecules, regulates stem cell properties, and modulates signal transduction pathways, making it relevant in various diseases and a pivotal factor in MSC-based therapies.

Other names: TNFAIP6TSG6TNF alpha induced protein 6

Biological functions

Anti-inflammatory activityExtracellular matrix organizationStem cell regulationSignal transduction modulationImmune regulation

Disease associations

Rheumatoid arthritisInflammatory bowel diseaseNeurodegenerative diseasesNeuroinflammationCancer

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